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KMID : 0374019800030010021
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Ewha Medical Journal
1980 Volume.3 No. 1 p.21 ~ p.25
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Effects of Exogenous Cholx Acid on Total Hepatic Cytochrome P-450 and b5 in the Bile Duct-ligated Rats
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Abstract
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We have investigated the effect of administration of exogenous cholic acid whether total hepatic cytochrome P-450 and b5 are altered in the bile duct-ligated rats.
The effect of administration of exogenous cholic acid on the hepatic microsomal mixed-function oxidase system is various according to the administration route, dosage and date after administration
In normal rats, 1ml of 0.5m Mol cholic acid solution per 1008 body weight administrated intravenously increases hepatic content of cytochrome P-450 and b5 on the third to fifth days after injection.
Total hepatic cytochrome P-450 and b5 are decreased after either bile duct ligation or the administration of ethinyl estradiol. In contrast when cholic acid is administrated simultaneously with bile duct ligation, the reduction in cytochrome P-450 is relatively prevented.
These effects are similar to the potential of phenobarbital for reversing the bile duct ligation-associated decrease in all components of the mixed function oxidase system.
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